Greater Manchester is now living with the highest tier of coronavirus restrictions, and South Yorkshire is to follow from 00:01 BST on Saturday.
The areas are moving from tier two (high risk), to tier three (very high risk) status, joining the Liverpool City Region and Lancashire.
Wales will move into a national circuit-breaker lockdown on Friday evening, while Scotland will announce details of a five-tier system of restrictions later on Friday.
Every area of England is now in one of three categories – medium (tier one), high (tier two) or very high (tier three), depending on the local infection rate.
Areas with the most rapidly rising transmission rates are placed in tier three.
You cannot meet anybody who is not part of your household or support bubble:
However, you can meet other people in parks, beaches, countryside or forests, in groups of up to six people.
Other rules include:
Extra measures can be introduced for individual areas.
In Lancashire, car boot sales are not allowed, while gyms in the Liverpool City Region initially closed but have now reopened. Gyms in South Yorkshire will stay open, but gym classes will not be allowed.
The Greater Manchester restrictions will be reviewed by at least 11 November.
Areas in tier one are subject to the basic national rules previously in force.
From 18:00 on Friday 23 October until the start of Monday 9 November, Wales will go into a ”short, sharp” circuit-break, a mini lockdown in which:
Adults living alone or single parents will be able to join with one other household for support from anywhere in Wales.
Northern Ireland has introduced four weeks of restrictions. Schools have closed for a two-week extended half-term break and will reopen on 2 November.
Other measures include:
Scotland is planning to introduce a five-tier system of restrictions in early November.
In the meantime, restrictions, which were due to run until 25 October, have been extended by another week.
This includes the tougher rules imposed on 3.4 million people in central Scotland.
The region affected covers 18 local council and five health board areas (Greater Glasgow & Clyde, Lanarkshire, Ayrshire & Arran, Lothian, Forth Valley).
In these areas, all licensed premises – except hotel bars for residents – must close indoors and outdoors, though takeaways are permitted.
Cafes can stay open until 18:00 daily, as long as they don’t serve alcohol.
People living in these areas have been told to avoid public transport, unless absolutely necessary, and not to leave their local areas if possible (people from outside are encouraged not to visit).
Other measures include the closing of snooker halls, bowling alleys, casinos and bingo halls, the suspension of non-professional contact sports and indoor group exercise for adults.
In the rest of Scotland, pubs and restaurants can only open inside between 06:00 and 18:00 daily, and are not allowed to serve alcohol.
They are only allowed to serve food and non-alcoholic drinks, although they can serve alcohol outdoors until 22:00.
Hotel restaurants can serve food after 18:00, but only for residents and without alcohol.
Throughout the nation, face coverings are compulsory in indoor communal settings, such as staff canteens and corridors in workplaces.